CCR5 Cancer Research Credit Bluemoon on I Villa
Post# of 148160
Credit Bluemoon on I Village
https://breast-cancer-research.biomedcentral....22-01528-w
Conclusions
Using a liquid biopsy approach, we evaluated two populations of tumor-associated cells emanating from primary tumors, with data suggesting that upregulation of the motility chemokine CCR5 in TACs provides clinically relevant opportunities for treating and tracking drug targetable receptors in mBC.
CCR5 signal is found to be low to nonexistent in primary BC tumors but upregulated in secondary sites of metastasis [2]. CCR5 regulates cancer cell migration, which indicates that CCR5 + cells may be more migratory in nature and may promote metastasis of disease[4]. This has been shown by elevated CCR5 signal being associated with increased tumor progression in highly invasive BC subtypes (i.e., basal and HER-2) [3, 5,6,7].
Introduction