UCLA researchers discover key molecular mechanism
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Posted On: 05/27/2022 12:23:38 PM
UCLA researchers discover key molecular mechanism behind memory linking
Maybe already posted.
Some excerpts below
"Now UCLA researchers have discovered a key molecular mechanism behind memory linking. They've also identified a way to restore this brain function in middle-aged mice – and an FDA-approved drug that achieves the same thing.
Published in Nature, the findings suggest a new method for strengthening human memory in middle age and a possible early intervention for dementia...
A bit of Biology 101: cells are studded with receptors. To enter a cell, a molecule must latch onto its matching receptor, which operates like a doorknob to provide access inside.
The UCLA team focused on a gene called CCR5 that encodes the CCR5 receptor-;the same one that HIV hitches a ride on to infect the brain cell and cause memory loss in AIDS patients.
Silva's lab demonstrated in earlier research that CCR5 expression reduced memory recall...
...Boosting CCR5 gene expression in the brains of middle-aged mice interfered with memory linking. The animals forgot the connection between the two cages.
When the scientists deleted the CCR5 gene in the animals, the mice were able to link memories that normal mice could not.
Silva had previously studied the drug, maraviroc, which the U.S. Food and Drug Administration approved in 2007 for the treatment of HIV infection. His lab discovered that maraviroc also suppressed CCR5 in the brains of mice....
https://www.news-medical.net/news/20220525/UC...nking.aspx
Maybe already posted.
Some excerpts below
"Now UCLA researchers have discovered a key molecular mechanism behind memory linking. They've also identified a way to restore this brain function in middle-aged mice – and an FDA-approved drug that achieves the same thing.
Published in Nature, the findings suggest a new method for strengthening human memory in middle age and a possible early intervention for dementia...
A bit of Biology 101: cells are studded with receptors. To enter a cell, a molecule must latch onto its matching receptor, which operates like a doorknob to provide access inside.
The UCLA team focused on a gene called CCR5 that encodes the CCR5 receptor-;the same one that HIV hitches a ride on to infect the brain cell and cause memory loss in AIDS patients.
Silva's lab demonstrated in earlier research that CCR5 expression reduced memory recall...
...Boosting CCR5 gene expression in the brains of middle-aged mice interfered with memory linking. The animals forgot the connection between the two cages.
When the scientists deleted the CCR5 gene in the animals, the mice were able to link memories that normal mice could not.
Silva had previously studied the drug, maraviroc, which the U.S. Food and Drug Administration approved in 2007 for the treatment of HIV infection. His lab discovered that maraviroc also suppressed CCR5 in the brains of mice....
https://www.news-medical.net/news/20220525/UC...nking.aspx
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