Article that pertains to CCR5 and also to Neandert
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Posted On: 02/24/2022 12:38:50 AM
Article that pertains to CCR5 and also to Neanderthals 50 to 70 thousand years ago. A genetic pick up from Neanderthals that helps with Covid-19 infection and what’s interesting is possibly blocking of CCR5 might stop one from being infected with smallpox too. Below is a excerpt of the article then a below that is the whole study/article.
One of the most well-studied genetic variants modulating infectious disease risk is a 32-base pair deletion that introduces a premature stop codon in CCR5, resulting in a nonfunctional receptor. This mutation, CCR5-Δ32, which confers protection against HIV-1 infection and likely also against smallpox, has been positively selected (5). HIV-1 relies on CD4 for viral entry and commonly requires also the chemokine receptors CCR5 and/or CXCR4 as coreceptors, even if it can also utilize CCR3 (6) and CXCR6 (7).
https://www.pnas.org/content/119/9/e2116435119You
One of the most well-studied genetic variants modulating infectious disease risk is a 32-base pair deletion that introduces a premature stop codon in CCR5, resulting in a nonfunctional receptor. This mutation, CCR5-Δ32, which confers protection against HIV-1 infection and likely also against smallpox, has been positively selected (5). HIV-1 relies on CD4 for viral entry and commonly requires also the chemokine receptors CCR5 and/or CXCR4 as coreceptors, even if it can also utilize CCR3 (6) and CXCR6 (7).
https://www.pnas.org/content/119/9/e2116435119You
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