This discussion of Cytolin has me wondering what i
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Posted On: 02/18/2022 2:46:53 PM
This discussion of Cytolin has me wondering what it's binding efficacy is. It binds to the CD11A side of the LFA-1 adhesion molecule. I knew LFA-1 was involved in Covid-19 but I had to look that up. The Orf7a Covid protein binds to LFA-1. I wonder if it would be worthwhile to dust that off and take a look at it. Since all Covid variants have Orf7a it should be variant agnostic.
Quote:
The main function of ORF7a is binding and preventing N-linked glycosylation of BST-2 (Bone marrow stromal antigen 2, also called CD317 or tetherin), therefore, blocking the tethering of SARS-CoV virions to the cytoplasmic membrane after they are released from the cell. Taylor JK et al. (2015) have reported that SARS-CoV ORF7a antagonizes the function of BST-2 and suggested that therapeutics designed to inhibit the interaction between BST-2 and ORF7a might be inhibiting virus growth both in vitro and in vivo.
http://www.bmrat.org/index.php/BMRAT/article/view/688
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