Memory function and CCR5. For fear of sequentia

Memory function and CCR5.

For fear of sequential over-posting, I'd like to share i little vein I was exploring earlier this week. As I mentioned, for the first time in over a year, I've advised a friend that he might want to purchase shares of Cytodyn. I advised the friend, that I can provide him some very high level reading, but I would need to be cautious about investment advise.

So I pointed him to several reliable sources including the banner at the Cytodyn website. I had sorta forgotten about the Memory papers posted on the Cytodyn Banner, so here's a reminder...followed by a note from yesterday's paper...

"Summary
Real world memories are formed in a particular context and are not acquired or recalled in isolation 19 1-5. Time is a key variable in the organization of memories, since events experienced close in time 20
are more likely to be meaningfully associated, while those experienced with a longer interval are not. How does the brain segregate events that are temporally distinct? Here, we report that a delayed (12-24h) increase in the expression of the C-C chemokine receptor type 5 (CCR5), an immune receptor well known as a co-receptor for HIV infection following the formation of a contextual memory, determines the duration of the temporal window for associating or linking that memory with subsequent memories. This delayed CCR5 expression in mouse dorsal CA1 (dCA1) neurons results in a decrease in neuronal excitability, which in turn negatively regulates neuronal memory allocation, thus reducing the overlap between dCA1 memory ensembles. Lowering this overlap affects the ability of one memory to trigger the recall of the other, thus closing the temporal window for memory linking. Remarkably, our findings also show that an age-related increase in CCL5/CCR5 expression leads to impairments in memory linking in aged mice, which could be reversed with a CCR5 knockout and an FDA approved drug that inhibits this receptor, a result with significant clinical implications. All together the findings reported here provide the first insights into the molecular and cellular mechanisms that shape the temporal window for memory linking."

https://d1io3yog0oux5.cloudfront.net/cytodyn/...1.full.pdf

And from the paper yesterday...

"Furthermore, high expression of CCR5 is associated with (...) suppression of cortical plasticity, learning, and memory."

http://journal.frontiersin.org/article/10.338...;id=794638

Before I forget,
Good luck to you,
chazzle