Many of the genetic mutations in ALS cause mitochondrial damage and it has been proposed this may be a primary cause.
An earlier post of mine may be relevant. You may want to peruse the entire post.
Quote:CCR5 blockade downregulates IL-13 leading to an increase in a1-antitrypsin and protection of mitochondria.
https://investorshangout.com/post/view?id=6231450