Kevetrin showed a biphasic time vs. drug concentration curve with an elimination half-life of about 0.7 to 2.2 hours in mice and rats, respectively, and 1 hour in dogs and a dose dependent pattern in terms of the plasma concentration, C max, and exposure. (you can see kevetrin AUC graph here: http://cellceutix.com/wp-content/uploads/2012...11x17.pdf)

Ctix and DF use a tool called the AUC graph to determine time to steady state. Steady state is the time is takes a drug to accumulate in the body until the rate of excretion equals the rate of intake. It is not a dose dependent thing - some drugs administered at 20mg once a day can reach steady state in a week, others administered at 400mg every 8 hours for a week will not reach steady state. The difference is the drugs half-life, which is normally thought of as the time it takes the body to first metabolize and then get rid of 50% of the drug.

Time to steady state is also effected by how the liver conjugates the drug and sometimes a single drug has one rate for plasma steady state and another for the rate of the drugs exchange between the plasma and the tissues.

Kevetrin has a short half life even at high doses. It would need frequent administrations to reach a steady state in animals. The company says it has a "low risk of accumulation". This is so good - because many of the most common chemo agents have long half lives, reach steady state quickly and have high risk of accumulation. So it will be acting very differently to kill cancer.

Regarding your question about tissue absorption. All drugs have some rate of tissue absorption. Some high, some low. Some have affinity towards certain areas, like fat, extracellular fluid, or specific tissues or tumors. Every drug is unique and getting a handle on a drugs pattern of distribution is a reason to do extensive preclinical and in human study. Kevetrin will be carried in the blood and distributed into tissue - but I don't know whether that tissue diffusion will be at a high or low rate. It will be excreted mostly through urine.

Keep asking questions. It keeps us on our toes.