CTMedic, thanks for the link: "Furthermore, the d
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Posted On: 10/28/2021 9:29:21 AM
CTMedic, thanks for the link:
"Furthermore, the diverse expression of ACE-2 in macrophages among individuals might govern the severity of SARS-CoV-2 infection.34 Macrophages in the lower airways are reported to have greater expression of the genes encoding for inflammatory chemokines and cytokines than those within the upper airways.32 These macrophages express pro-inflammatory cytokines including IL-8, IL-1β, and TNF-α and various chemokines including CCL2, CCL3, CCL5 (RANTES), CXCL1, CXCL3, and CXCL10 and this macrophage subpopulation likely contributes to excessive lung inflammation by promoting further monocyte recruitment and macrophage differentiation.32 Activated platelets interact with circulating monocytes producing platelet–monocyte aggregates that likely potentiate pulmonary monocyte recruitment and activation.35"
"Furthermore, the diverse expression of ACE-2 in macrophages among individuals might govern the severity of SARS-CoV-2 infection.34 Macrophages in the lower airways are reported to have greater expression of the genes encoding for inflammatory chemokines and cytokines than those within the upper airways.32 These macrophages express pro-inflammatory cytokines including IL-8, IL-1β, and TNF-α and various chemokines including CCL2, CCL3, CCL5 (RANTES), CXCL1, CXCL3, and CXCL10 and this macrophage subpopulation likely contributes to excessive lung inflammation by promoting further monocyte recruitment and macrophage differentiation.32 Activated platelets interact with circulating monocytes producing platelet–monocyte aggregates that likely potentiate pulmonary monocyte recruitment and activation.35"
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