Anyone know if QD glow in a CT Scan? Another QD Pr
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Posted On: 10/25/2021 11:29:03 PM
Re: Puravida19 #21099
Anyone know if QD glow in a CT Scan?
Another QD Product Gold NP can.
Possible use in Mr. Miller's company or future us in other products -
QD can light up under x-rays -
Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse
Sean G Ryan et al. Sci Rep. 2019.
Abstract
Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles, but optical scattering and absorption limit the depth and resolution in both animal and human subjects. Two new hybrid approaches are presented, using the penetrating power of X-rays to increase the depth of optical imaging. Foremost, we demonstrate the excitation by X-rays of quantum-dots (QD) emitting in the near-infrared (NIR), using a clinical X-ray system to map the distribution of QDs at depth in whole mouse. We elicit a clear, spatially-resolved NIR signal from deep organs (brain, liver and kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in vivo applications. Furthermore, X-ray-excited endogenous emission is also detected from whole mouse. The use of keV X-rays to excite emission from QDs and tissue represent novel biomedical imaging technologies, and exploit emerging QDs as optical probes for spatial-temporal molecular imaging at greater depth than previously possible.
Another QD Product Gold NP can.
Possible use in Mr. Miller's company or future us in other products -
QD can light up under x-rays -
Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse
Sean G Ryan et al. Sci Rep. 2019.
Abstract
Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles, but optical scattering and absorption limit the depth and resolution in both animal and human subjects. Two new hybrid approaches are presented, using the penetrating power of X-rays to increase the depth of optical imaging. Foremost, we demonstrate the excitation by X-rays of quantum-dots (QD) emitting in the near-infrared (NIR), using a clinical X-ray system to map the distribution of QDs at depth in whole mouse. We elicit a clear, spatially-resolved NIR signal from deep organs (brain, liver and kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in vivo applications. Furthermore, X-ray-excited endogenous emission is also detected from whole mouse. The use of keV X-rays to excite emission from QDs and tissue represent novel biomedical imaging technologies, and exploit emerging QDs as optical probes for spatial-temporal molecular imaging at greater depth than previously possible.
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