CTMedic was kind enough to send me a link to a stu
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Posted On: 10/14/2021 8:46:45 PM
CTMedic was kind enough to send me a link to a study.
Quote:
Increased mTOR signaling, impaired autophagic flux and cell-to-cell viral transmission are hallmarks of SARS-CoV-2 infection.
Our findings reveal that SARS-CoV-2 infection in Vero E6 cells and severe COVID-19 patients occur in conditions of increased mTOR activity and impaired autophagic flux that could prevent the viral release and promote cell-to-cell viral transmission.
https://www.biorxiv.org/content/10.1101/2021.10.13.464225v1Quote:
My earlier proposed anti-viral activity of leronlimab -
Quote:
CCR5 blockade of CCL5 disrupts the PI3K/AKT/mTOR/4E-BP1 pathway dysregulating elF4E. With elF4E disrupted the COVID-19 virus 5' -end cap would be unable to separate it's mRNA and duplicate.
Elevated mTOR would increase viral reproduction. If I remember correctly CA2+ is also necessary to the viral reproduction process and leronlimab downregulates that. Which is why I think a properly done mild/moderate trial could beat molnupiravir and REGN-COV2.
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