Sent the following to Nader in Sept. While I don'
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Posted On: 10/07/2021 11:51:49 AM
Sent the following to Nader in Sept. While I don't think it helped with todays stroke announcement, I don't think it hurt.
Attn: N Pourhassan
The stroke and traumatic brain injury findings in this study from Cell dated 2019 dovetails so perfectly with the LL MoA that I just had to share. BoL.
CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury (cell.com)
D
Study excerpts: "..., CCR5 is a translational target for neural repair in stroke and TBI and the first reported gene associated with enhanced recovery in human stroke"
"... While the biology of neural repair in adult brain in juries such as stroke and TBI is increasingly defined (Grafman and Salazar, 2015), there have been no medical therapies developed to promote recovery in these" injuries.
""... As stroke induces neuronal expression of CCR5, and increased CCR5 signaling is associated with reduced learning and memory (Zhou et al., 2016), we examined if neuron-specific knockdown of CCR5 in pre-motor cortex promotes stroke recovery. Neuronal plasticity in pre-motor-to-motor circuits after stroke in motor cortex is causally associated with motor recovery (Clarkson et al., 2010, 2011; Overman et al., 2012; Li et al., 2015).
https://www.cell.com/cell/pdf/S0092-8674(19)30107-2.pdf
Attn: N Pourhassan
The stroke and traumatic brain injury findings in this study from Cell dated 2019 dovetails so perfectly with the LL MoA that I just had to share. BoL.
CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury (cell.com)
D
Study excerpts: "..., CCR5 is a translational target for neural repair in stroke and TBI and the first reported gene associated with enhanced recovery in human stroke"
"... While the biology of neural repair in adult brain in juries such as stroke and TBI is increasingly defined (Grafman and Salazar, 2015), there have been no medical therapies developed to promote recovery in these" injuries.
""... As stroke induces neuronal expression of CCR5, and increased CCR5 signaling is associated with reduced learning and memory (Zhou et al., 2016), we examined if neuron-specific knockdown of CCR5 in pre-motor cortex promotes stroke recovery. Neuronal plasticity in pre-motor-to-motor circuits after stroke in motor cortex is causally associated with motor recovery (Clarkson et al., 2010, 2011; Overman et al., 2012; Li et al., 2015).
https://www.cell.com/cell/pdf/S0092-8674(19)30107-2.pdf
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