The article that onestep ahead posted (https://www
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Posted On: 10/05/2021 1:17:20 PM
The article that onestep ahead posted (https://www.bloomberg.com/news/articles/2021-10-05/long-covid-symptoms-may-be-caused-by-micro-clots-scientists-say), referenced a very interesting bit of LH/PASC research from South Africa.
Researchers there found microemboli that were atypically persistent/resistant to normal physiologic degradation.
https://cardiab.biomedcentral.com/track/pdf/1...1359-7.pdf
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels
of antiplasmin
The truth of PASC is likely to defy explanation, but this is a provocative study.
Researchers there found microemboli that were atypically persistent/resistant to normal physiologic degradation.
https://cardiab.biomedcentral.com/track/pdf/1...1359-7.pdf
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels
of antiplasmin
Quote:
We show that plasma samples from Long COVID/PASC still contain large anomalous (amyloid) deposits (microclots). We also show that these microclots in both acute COVID-19 and Long COVID/PASC plasma samples are resistant to fibrinolysis (compared to plasma from controls and T2DM), even after trypsinisation. After a second trypsi- nization, the persistent pellet deposits (microclots) were solubilized. We detected various inflammatory molecules that are substantially increased in both the supernatant and trapped in the solubilized pellet deposits of acute COVID- 19 and Long COVID/PASC, versus the equivalent volume of fully digested fluid of the control samples and T2DM. Of particular interest was a substantial increase in α(2)-antiplasmin (α2AP), various fibrinogen chains, as well as Serum Amyloid A (SAA) that were trapped in the solubilized fibrinolytic-resistant pellet deposits.
The truth of PASC is likely to defy explanation, but this is a provocative study.
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