Remdisavir vs Favipiravir with Brilacidin: any dif
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Posted On: 09/20/2021 9:00:10 PM
Remdisavir vs Favipiravir with Brilacidin: any diff?
Favipiravir was used as the SOC in the Russian phase 2 trials in 106 trial cases.
Remdisavir was used as the SOC in the US phase 2 trials in X number of trial cases.
Answer = No
GMU details follow:
Brilacidin in Combination with Other Antiviral Treatments: Synergistic Activity against SARS-CoV-2 in Combination with Remdesivir in Calu-3 Cells
As brilacidin appears to act primarily by disrupting viral integrity and inhibiting viral entry, combining the drug with antiviral treatments that have a different mechanism of action may result in synergistic inhibition when administered in combination. The potential for brilacidin to exert a synergistic inhibition of SARS-CoV-2 when combined with current frontline COVID-19 antiviral treatments, namely, remdesivir and favipiravir, was assessed. Potential toxicity of combinations of remdesivir or favipiravir with brilacidin were initially assessed in the Calu-3 cell line at 24 h post-treatment. No apparent toxicity could be detected up to a 10 µM concentration of each of the drugs in the combination regimen. To evaluate the efficacy of combining remdesivir or favipiravir with brilacidin, the cells were pretreated with brilacidin for 2 h. The virus inoculum was also independently preincubated with brilacidin for 1 h, and then the treated inoculum was overlaid on cells and the infection allowed to proceed for 1 h in the presence of brilacidin. Postinfection, the inoculum was removed and media containing both brilacidin and remdesivir or favipiravir or each drug alone for efficacy comparison were added to the infected cells. Supernatants were obtained at 24 h postinfection and infectious titer was quantified by plaque assay. The data revealed that brilacidin and favipiravir independently exerted up to 90% and 80% inhibition, respectively, and the extent of inhibition did not increase over that exerted by brilacidin alone when the two drugs were used in combination (Figure 5A). In contrast, combination of brilacidin with remdesivir at 10 and 2.5 µM concentrations, respectively, reduced the viral infectious titer by >99%, thus providing a highly effective inhibition profile (Figure 5B) and achieving greater inhibition than with either compound alone. This synergistic inhibition continued to remain higher than 99% when the concentrations of both compounds were equal ..
Extract from
1. National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
2
Public Health Research Institute, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, NJ 07103, USA
3
Innovation Pharmaceuticals Inc., Wakefield, MA 01880, USA
Favipiravir was used as the SOC in the Russian phase 2 trials in 106 trial cases.
Remdisavir was used as the SOC in the US phase 2 trials in X number of trial cases.
Answer = No
GMU details follow:
Brilacidin in Combination with Other Antiviral Treatments: Synergistic Activity against SARS-CoV-2 in Combination with Remdesivir in Calu-3 Cells
As brilacidin appears to act primarily by disrupting viral integrity and inhibiting viral entry, combining the drug with antiviral treatments that have a different mechanism of action may result in synergistic inhibition when administered in combination. The potential for brilacidin to exert a synergistic inhibition of SARS-CoV-2 when combined with current frontline COVID-19 antiviral treatments, namely, remdesivir and favipiravir, was assessed. Potential toxicity of combinations of remdesivir or favipiravir with brilacidin were initially assessed in the Calu-3 cell line at 24 h post-treatment. No apparent toxicity could be detected up to a 10 µM concentration of each of the drugs in the combination regimen. To evaluate the efficacy of combining remdesivir or favipiravir with brilacidin, the cells were pretreated with brilacidin for 2 h. The virus inoculum was also independently preincubated with brilacidin for 1 h, and then the treated inoculum was overlaid on cells and the infection allowed to proceed for 1 h in the presence of brilacidin. Postinfection, the inoculum was removed and media containing both brilacidin and remdesivir or favipiravir or each drug alone for efficacy comparison were added to the infected cells. Supernatants were obtained at 24 h postinfection and infectious titer was quantified by plaque assay. The data revealed that brilacidin and favipiravir independently exerted up to 90% and 80% inhibition, respectively, and the extent of inhibition did not increase over that exerted by brilacidin alone when the two drugs were used in combination (Figure 5A). In contrast, combination of brilacidin with remdesivir at 10 and 2.5 µM concentrations, respectively, reduced the viral infectious titer by >99%, thus providing a highly effective inhibition profile (Figure 5B) and achieving greater inhibition than with either compound alone. This synergistic inhibition continued to remain higher than 99% when the concentrations of both compounds were equal ..
Extract from
1. National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
2
Public Health Research Institute, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, NJ 07103, USA
3
Innovation Pharmaceuticals Inc., Wakefield, MA 01880, USA
(3)
(0)Innovation Pharmaceuticals Inc (IPIX) Stock Research Links
Ronald A Phillips
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