Great find! The TBI info is interesting. “Neuro
Post# of 154117
(Total Views: 381)
Posted On: 09/18/2021 12:35:32 PM
Great find! The TBI info is interesting. “Neurological impairments and cognitive function” Sounds like we have something to look at for Alzheimer’s. It would be amazing to help people with Alzheimer’s.
“We tested a newly described molecular memory sys- tem, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre- motor cortex leads to early recovery of motor control. Recovery is associated with preservation of dendritic spines, new patterns of cortical projections to contralateral pre-motor cortex, and upregulation of CREB and DLK signaling. Administration of a clinically utilized FDA-approved CCR5 antagonist, devised for HIV treatment, produces similar effects on motor recovery post stroke and cognitive decline post TBI. Finally, in a large clinical cohort of stroke patients, carriers for a naturally occurring loss-of- function mutation in CCR5 (CCR5-D32) exhibited greater recovery of neurological impairments and cognitive function. In summary, CCR5 is a transla- tional target for neural repair in stroke and TBI and the first reported gene associated with enhanced re- covery in human stroke.”
“We tested a newly described molecular memory sys- tem, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre- motor cortex leads to early recovery of motor control. Recovery is associated with preservation of dendritic spines, new patterns of cortical projections to contralateral pre-motor cortex, and upregulation of CREB and DLK signaling. Administration of a clinically utilized FDA-approved CCR5 antagonist, devised for HIV treatment, produces similar effects on motor recovery post stroke and cognitive decline post TBI. Finally, in a large clinical cohort of stroke patients, carriers for a naturally occurring loss-of- function mutation in CCR5 (CCR5-D32) exhibited greater recovery of neurological impairments and cognitive function. In summary, CCR5 is a transla- tional target for neural repair in stroke and TBI and the first reported gene associated with enhanced re- covery in human stroke.”
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