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Hmmmmm. I wonder if this study will help us.

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Post# of 155004
(Total Views: 758)
Posted On: 08/28/2021 10:24:46 AM
Posted By: peacekat
Hmmmmm. I wonder if this study will help us.

https://www.wsj.com/articles/unlike-clinical-...yURL_share


Med­ical stud­ies of­ten use thou-sands of vol­un­teers. But some-times good things come in small pack­ages—like a hand­ful of peo­ple will­ing to con­tract a deadly virus.
Re­searchers in the U.K. have de­lib­er­ately in­fected 30 vol­un­teers with the virus that causes Covid-19, in the first hu­man chal­lenge study of the dis­ease. In­fect­ing the vol­un­teers—who are healthy, un­vac­ci­nated and range in age from 18 to 30—will al­low the sci­en­tists to ob­serve in real time how the virus at­tacks the body and, from the mo­ment of ex­po­sure, how the im­mune sys­tem re­sponds.
The vol­un­teers are un­der 24-hour study in a hos­pi­tal res­i­den­tial fa­cil­ity, al­low­ing the re­searchers to, among other things, mea­sure their vi­ral load twice daily in the nose and throat, per­form mul­ti­ple blood tests, col­lect urine or stool sam­ples if needed and mea­sure an­ti­bod­ies in the mu­cus from the res­pi­ra­tory tract and in the blood, ac­cord­ing to Pe­ter Open­shaw, a pro­fes­sor of ex­per­i­men­tal med­i-cine at Im­pe­r­ial Col­lege Lon­don and a co-in­ves­ti­ga­tor on the study.
“Be­cause we can take so many dif­fer­ent sam­ples, we can get ex­traordinary in­sight into how the virus causes dis­ease,” Dr. Open-shaw said. “We are learn­ing more about the twists and the tails this virus has and the ways it can cause prob­lems in other or­gans. It’s all very im­por­tant in learn­ing how to pre­vent those com­pli­ca­tions.”
Hu­man chal­lenge stud­ies are dif­fer­ent from ran­dom­ized clin­i­cal tri­als, the pri­mary way re­searchers find out if vac­cines and other ther­a­pies are safe and ef­fec­tive.
In clin­i­cal tri­als, re­searchers take a large num­ber of peo­ple, give half a vac­cine and half a placebo, and send them on their way to be nat­u­rally ex­posed to the virus, said Kath­leen Neuzil, di­rec­tor of the Cen­ter for Vac­cine De­vel­op­ment and Global Health at the Uni­ver­sity of Mary­land School of Med­i­cine. A clin­i­cal trial in the U.S. of Covid-19 vac­cines used more than 30,000 vol­un­teers.
But sim­i­lar stud­ies have been used for cen­turies, at times rais­ing eth­i­cal con­cerns.
Be­fore a Covid-19 vac­cine or other ther­a­pies were avail­able, the idea of in­ten­tion­ally in­fect­ing peo­ple with the deadly virus that causes the dis­ease also gen­er­ated de­bate, and a pri­mary goal of the U.K. study is to de­ter­mine the low­est pos­si­ble dose of virus re­quired to make vol­un­teers sick so that sci­en­tists can study the dis­ease while plac­ing par­tic­i­pants at min­i­mal risk.
The study, which be­gan in March and is ex­pected to con­clude in Sep­tember, has al­ready re­vealed new in­for­ma­tion, the re­searchers said, but be­cause their find­ings have yet to be pub­lished, they wouldn’t dis­close the de­tails. The Im­pe­r­ial Col­lege Lon­don re­search is sup­ported with an in­vest­ment of £33.6 mil­lion, equiv­a­lent to $46 mil­lion, from the U.K. gov­ern­ment, an amount ex­pected to sup­port this and fu­ture re­search.


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