Ohm wrote:
That makes terrific sense, in my opinion. We remember that in the trial's preliminary results Leron did well in 18 of the 24 symptoms:
"Clinically meaningful improvements in leronlimab over placebo were observed for cough, stuffy/runny nose, shortness of breath, tightness of chest, feeling of fast heartbeat, fatigue, muscle aches/cramps, muscle weakness, joint pain/swelling, chills/shivering, feeling hot or feverish, difficulty in concentration, sleep disturbance/insomnia, headache, dizziness, tingling/numbness, sense of taste, and sense of smell. Of the remaining 6 symptoms, sore throat, exertional malaise, anxiety, nausea, and vomiting had no clinically meaningful change. Diarrhea was worse in leronlimab treated compared to placebo."
Three of the seven symptoms not relieved by Leron were digestive -- nausea, diarrhea, vomiting. Two of the seven are psychic conditions that are hard to pin down, both in terms of cause and effect -- anxiety and Malaise. Sore throat is inflammation.
Of the 18 symptoms which DID improve, a number of them are or could be neurological: sleep disturbance, tingling/numbness, sense of taste, sense of smell, difficulty in concentration, perhaps dizziness. (I'm not sure if chronic fatigue and muscle weakness could be seen as neurological.)
If we can prove that Leron has positive effect on neurological symptoms, it might open the door for testing on neurological diseases like Parkinson's and Alzheimer's. That would be BIG.
I could be way off here, and welcome someone straightening me out, like Ohm or CTMedic. Thanks.
Quote:From the CARE Georgia website where we did our longhaulers trial.
Quote:
We are planning for another long-hauler COVID trial focusing on neurological effects to begin late August/September
That makes terrific sense, in my opinion. We remember that in the trial's preliminary results Leron did well in 18 of the 24 symptoms:
"Clinically meaningful improvements in leronlimab over placebo were observed for cough, stuffy/runny nose, shortness of breath, tightness of chest, feeling of fast heartbeat, fatigue, muscle aches/cramps, muscle weakness, joint pain/swelling, chills/shivering, feeling hot or feverish, difficulty in concentration, sleep disturbance/insomnia, headache, dizziness, tingling/numbness, sense of taste, and sense of smell. Of the remaining 6 symptoms, sore throat, exertional malaise, anxiety, nausea, and vomiting had no clinically meaningful change. Diarrhea was worse in leronlimab treated compared to placebo."
Three of the seven symptoms not relieved by Leron were digestive -- nausea, diarrhea, vomiting. Two of the seven are psychic conditions that are hard to pin down, both in terms of cause and effect -- anxiety and Malaise. Sore throat is inflammation.
Of the 18 symptoms which DID improve, a number of them are or could be neurological: sleep disturbance, tingling/numbness, sense of taste, sense of smell, difficulty in concentration, perhaps dizziness. (I'm not sure if chronic fatigue and muscle weakness could be seen as neurological.)
If we can prove that Leron has positive effect on neurological symptoms, it might open the door for testing on neurological diseases like Parkinson's and Alzheimer's. That would be BIG.
I could be way off here, and welcome someone straightening me out, like Ohm or CTMedic. Thanks.
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