"If long-lived monocytes encapsulating viral parti
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Posted On: 08/01/2021 8:15:18 PM
"If long-lived monocytes encapsulating viral particles is the cause of longhaulers why aren't patients at 15-16 months going into remission?"
An excellent question. Patterson only knows that the spike protein is inside the monocytes and that these particular monocytes are published as "long-lived". Patterson has no way of measuring either the "age" of the monocytes he found or the tissue that they picked up the spike protein in.
1) Monocyte halflife is highly variable amongst humans. Lomghaulers could be humans with longer moncyte half-lives
2) covid reservoir somewhere in the body could offer a continuous supply of fresh migrating monocytes
3) Its the inflammation that is long lived. Once the monocytes migrate to the tissue and cause symptoms, the inflammatory response clears the monocytes and the residual spike protein but the inflammation persists. Maybe its not a continuous stream of monocytes that causes the inflammation. Perhaps the monocyte migration is only a spike and its the effect of the migration that persists.
"The binding of the monocytes to blood vessels is caused by Intercellular Adhesion Molecule 1..."
Does Intercellular Adhesion Molecule have a drug that docs could use? Or even something that might work in a test tube?
"Patterson's kit is a collection of already existing tests."
My suspicion is that cytokine tests results of different labs are not equal to each other, but I don't know. In other words, two labs that each measure RANTES will not get the same results on the same blood sample. This situation is suggested by the fact that only certain clinical laboratories are qualified to run Patterson's kits. Patterson claims that the very widely used PSA test for prostate cancer is not reproducible between labs. Seems like each lab has its own test, and while that test may be FDA qualified, part of the FDA qualification process does not include matching to other FDA approved tests which test for the same molecule. Perhaps this situation is not surprising as different labs can use different intellectual property to conduct testing of the same molecule.
An excellent question. Patterson only knows that the spike protein is inside the monocytes and that these particular monocytes are published as "long-lived". Patterson has no way of measuring either the "age" of the monocytes he found or the tissue that they picked up the spike protein in.
1) Monocyte halflife is highly variable amongst humans. Lomghaulers could be humans with longer moncyte half-lives
2) covid reservoir somewhere in the body could offer a continuous supply of fresh migrating monocytes
3) Its the inflammation that is long lived. Once the monocytes migrate to the tissue and cause symptoms, the inflammatory response clears the monocytes and the residual spike protein but the inflammation persists. Maybe its not a continuous stream of monocytes that causes the inflammation. Perhaps the monocyte migration is only a spike and its the effect of the migration that persists.
"The binding of the monocytes to blood vessels is caused by Intercellular Adhesion Molecule 1..."
Does Intercellular Adhesion Molecule have a drug that docs could use? Or even something that might work in a test tube?
"Patterson's kit is a collection of already existing tests."
My suspicion is that cytokine tests results of different labs are not equal to each other, but I don't know. In other words, two labs that each measure RANTES will not get the same results on the same blood sample. This situation is suggested by the fact that only certain clinical laboratories are qualified to run Patterson's kits. Patterson claims that the very widely used PSA test for prostate cancer is not reproducible between labs. Seems like each lab has its own test, and while that test may be FDA qualified, part of the FDA qualification process does not include matching to other FDA approved tests which test for the same molecule. Perhaps this situation is not surprising as different labs can use different intellectual property to conduct testing of the same molecule.
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