Stinkypennies, I thought he did a really great job in recruiting for the sites but I may be wrong, (correct me if I am), but by doing so well at recruiting he might have also brought in too many of the severe enrolled and that could have skewed the balance between severe and critical in the CD-12 trial.
Now, don't bombard me if I'm wrong as I have been thinking that is what happened in the CD-12 trial it was too many severe and hurt the P-value of the trial. Lastly, I think you are talking about Brothen, right? - GLTU SP