Investors Hangout Stock Message Boards Logo
  • Mailbox
  • Favorites
  • Boards
    • The Hangout
    • NASDAQ
    • NYSE
    • OTC Markets
    • All Boards
  • Whats Hot!
    • Recent Activity
    • Most Viewed Boards
    • Most Viewed Posts
    • Most Posted
    • Most Followed
    • Top Boards
    • Newest Boards
    • Newest Members
  • Blog
    • Recent Blog Posts
    • Recently Updated
    • News
    • Stocks
    • Crypto
    • Investing
    • Business
    • Markets
    • Economy
    • Real Estate
    • Personal Finance
  • Market Movers
  • Interactive Charts
  • Login - Join Now FREE!
  1. Home ›
  2. Stock Message Boards ›
  3. Stock Boards ›
  4. CytoDyn Inc (CYDY) Message Board

I'll let ohm chime in as he knows the pathways inc

Message Board Public Reply | Private Reply | Keep | Replies (2)                   Post New Msg
Edit Msg () | Previous | Next


Post# of 155000
(Total Views: 490)
Posted On: 07/26/2021 8:58:59 PM
Posted By: thriftycents
Re: Buddyboy20 #97443
I'll let ohm chime in as he knows the pathways incredibly well but just to point out that Polycythemia Vera Leukemia is a type of myeloproliferative neoplasms (MPN). This article seems to go into depth with regards to this type of blood cancer and cytokines

https://www.sciencedirect.com/science/article...3219300047

Quote:
The data summarized above clearly demonstrate that MPN-associated oncogenes can trigger inflammatory responses of both the malignant and nonmalignant cells. However, it is conceivable that chronic inflammation itself may lead to an MPN.



Furthermore, a quick scan of the literature and it looks like inhibiting JAK1 and JAK2 has been studied

Quote:
These data suggest that inhibition of JAK1 and JAK2 by ruxolitinib can efficiently reduce the malignant clone in some MF patients, potentially by removing some of the MPN-promoting cytokines such as TNF-α, but that it additionally antagonizes inflammatory processes in nonmalignant cells



Quote:
Further data from mouse models suggest that a stronger inhibition of the mutant JAK2 protein or its signal transduction pathways, either by genetic ablation of JAK2 or by combination of ruxolitinib with other drugs, may improve the treatment of MPNs



Based on ohm's oft quoted list

Quote:
leronlimab regulates -

MapK, Erk 1 and 2, Jak 1, 2 and 3, ATP, mTORc1, TNF-a, TNFSF14, IFNy, NF-kb, bradykinin, NETosis, neuropin-1, PI3k, GM-CSF, IL1b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, IL-17, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL16, VEGF, SYK, SHP1, SHP2, PD-1, C5a, CA-2+,CD38, collagen, macrophage differentiation, TGF-b



We know that leronlimab does target JAK1/2. Curious to hear what ohm has to add, but I had looked at blood cancers before so wanted to share what I had found.

Sorry to hear that your friend is going through this. Wishing him/her healing thoughts!!!





(8)
(0)




CytoDyn Inc (CYDY) Stock Research Links


  1.  
  2.  


  3.  
  4.  
  5.  






Investors Hangout

Home

Mailbox

Message Boards

Favorites

Whats Hot

Blog

Settings

Privacy Policy

Terms and Conditions

Disclaimer

Contact Us

Whats Hot

Recent Activity

Most Viewed Boards

Most Viewed Posts

Most Posted Boards

Most Followed

Top Boards

Newest Boards

Newest Members

Investors Hangout Message Boards

Welcome To Investors Hangout

Stock Message Boards

American Stock Exchange (AMEX)

NASDAQ Stock Exchange (NASDAQ)

New York Stock Exchange (NYSE)

Penny Stocks - (OTC)

User Boards

The Hangout

Private

Global Markets

Australian Securities Exchange (ASX)

Euronext Amsterdam (AMS)

Euronext Brussels (BRU)

Euronext Lisbon (LIS)

Euronext Paris (PAR)

Foreign Exchange (FOREX)

Hong Kong Stock Exchange (HKEX)

London Stock Exchange (LSE)

Milan Stock Exchange (MLSE)

New Zealand Exchange (NZX)

Singapore Stock Exchange (SGX)

Toronto Stock Exchange (TSX)

Contact Investors Hangout

Email Us

Follow Investors Hangout

Twitter

YouTube

Facebook

Market Data powered by QuoteMedia. Copyright © 2025. Data delayed 15 minutes unless otherwise indicated (view delay times for all exchanges).
Analyst Ratings & Earnings by Zacks. RT=Real-Time, EOD=End of Day, PD=Previous Day. Terms of Use.

© 2025 Copyright Investors Hangout, LLC All Rights Reserved.

Privacy Policy |Do Not Sell My Information | Terms & Conditions | Disclaimer | Help | Contact Us