I was just telling my brother-in-law about this st
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Posted On: 07/09/2021 12:47:04 PM
I was just telling my brother-in-law about this study over the long 4th of July weekend. Also that Patterson's group found some interesting things about Covid long-haulers (signature of immune dysregulation, persistent spike protein presentation on monocytes), and would be soon tackling Lyme's disease and ME/CFS/FM. It will be interesting to see what specific immune dysregulation shows up for those few conditions, and if CCR5 blockade might have a role.
The paper is validation that fibromyalgia is a "real" disease with organic etiology, specifically with an auto-antibody component. I would think that increasing T-Regs would be a good approach to knocking down the auto-immune aspects of FM. Better would be something to stop the (memory?) B-cells from producing so many harmful antibodies that appear to sensitize various sensory receptors (CABA has an interesting approach for this). Not sure of the role of blocking CCR5 if it's just antibodies causing the symptoms, but there are CCR5 receptors on B-cells too.
The paper is validation that fibromyalgia is a "real" disease with organic etiology, specifically with an auto-antibody component. I would think that increasing T-Regs would be a good approach to knocking down the auto-immune aspects of FM. Better would be something to stop the (memory?) B-cells from producing so many harmful antibodies that appear to sensitize various sensory receptors (CABA has an interesting approach for this). Not sure of the role of blocking CCR5 if it's just antibodies causing the symptoms, but there are CCR5 receptors on B-cells too.
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