Doctors, do I have this right? Thanks in advance.
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Posted On: 06/04/2021 5:06:18 PM
Doctors, do I have this right? Thanks in advance.
So in other words, what they're saying below..
Whether the virus is destroyed by an antiviral (like Ivermectin?) or antibodies (natural or via vaccine)
the circulating debris from destroyed virus (i.e., the "spikes"
appear to cause brain clots/inflammation.
*******************
"The ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart.
They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudo-virions) that travel through the circulation and bind to ACE- 2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines.
Meinhardt et al. (Nature Neuroscience 2020, in
press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus”.
"This implies that the spike, on its very own, could act like a pathogen, causing devastating morbidity and fatality."
***************************
viral lysis - disruption of cellular membranes, leading to cell death
virions - a virus outside a host cell, with a core of RNA or DNA and a capsid.
capsid - the protien cage/shell of a virus to protect the viral genome from environmental conditions
pseudo-virions - viral particle that cannot replicate
viral capsid proteins (or pseudo-virions) - ??
mannan-binding lectin - plays an important role in the body's immune response by attaching to foreign invaders such as bacteria, viruses
vascular endothelium - the inner cellular lining of arteries, veins and capillaries and therefore is in direct contact with the components and cells of blood.
*************************
solution?
So in other words, what they're saying below..
Whether the virus is destroyed by an antiviral (like Ivermectin?) or antibodies (natural or via vaccine)
the circulating debris from destroyed virus (i.e., the "spikes"
appear to cause brain clots/inflammation. *******************
"The ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart.
They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudo-virions) that travel through the circulation and bind to ACE- 2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines.
Meinhardt et al. (Nature Neuroscience 2020, in
press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus”.
"This implies that the spike, on its very own, could act like a pathogen, causing devastating morbidity and fatality."
***************************
viral lysis - disruption of cellular membranes, leading to cell death
virions - a virus outside a host cell, with a core of RNA or DNA and a capsid.
capsid - the protien cage/shell of a virus to protect the viral genome from environmental conditions
pseudo-virions - viral particle that cannot replicate
viral capsid proteins (or pseudo-virions) - ??
mannan-binding lectin - plays an important role in the body's immune response by attaching to foreign invaders such as bacteria, viruses
vascular endothelium - the inner cellular lining of arteries, veins and capillaries and therefore is in direct contact with the components and cells of blood.
*************************
solution?
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