SARS-CoV-2 variant proof - to clarify. Lerolimab might not be effective for amino acid substitutions or INDELs in the second extracellular loop of CCR5. Other Mabs may also be SARS-CoV-2 variant proof, such as Narsoplimab, which is in I-SPY and has an FDA action date in July for TMA after HSCT.