With all the discussion about SI, going on on the other board, JFM has posted a reply that I believe is pertinent to the SI numbers so I am posting it for the boards consideration.
From JFM:
Post sites article in Nature (journal) that states several "substances" with very low SI showed "little" effect on virus replication OR showed SEVERE ADVERSE EFFECT in human patients....
1. WHY WOULDN"T THEY SHOW "LITTLE" effect...THEY HAD VERY LOW SI SCORES!!! IN FACT, All these "Substances" COMBINED did not match BRILACIDIN'S SI SCORE *426*. TO COMPARE THESE SUBSTANCES TO OR ANY SUBSTANCE in competition with BRILACIDIN...the substance being compared (which there are NONE) would be "SI" Score of 426...THERE ARE NO OTHERS! So, the comparative statement is comparing rotten apples to juicy oranges.
2. AGAIN...BRILACIN's SI's 426 SCORE is greater than ALL THOSE SUBSTANCES SI SCORE COMBINED and they showed "Little effect", therefore it is reasonable to expect Brilacidin, with 10X SI score of substances cited,...to show SIGNIFICANTLY MORE EFFECT on Covid viral suppression.
3. SAE COMPARISON? as is noted in quote...those OTHER SUBSTANCES "...led to SAE (severe adverse events and side effects) in human patients."...OK...but BRILACIDIN throughout PHASE II Clinical Trials for 5 Different Indications...BRILACIDIN has NEVER CAUSED a single SAE.
So what these "other" substances do it totally irrelevant to Brilacidin.
Quote:
"...several substances like Remdesivir, Lopinavir and Chloroquine were reported to repress viral replication in vitro. However, these compounds showed little effect on virus replication or led to severe adverse side effects in human patients." Bottom line: is that the
in vitro assays in cells did not predict clinical behavior.
Conclusion:
SUBSTANCES WITH Small SI SCORES showed small SUPRESSION of VIRAL SUPPRESSION in Clincial Trials...therefore Substances (Brilacidin) with EXTREMELY HIGH (HIGHEST) SI SCORE OF POTENTIAL THERAPEUTICS ... will likely demonstate in Clinical Trials EXTREMELY HIGH VIRAL SUPPRESSION in current clinicatl trials...compared to the substances sited.
Thank you for providing a post to further demonstrate the GREAT POTENTIAL of BRILACIDIN vs. Covid-19 IMO soon to be demonstrated in the current Clinical Trials!
From JFM:
Post sites article in Nature (journal) that states several "substances" with very low SI showed "little" effect on virus replication OR showed SEVERE ADVERSE EFFECT in human patients....
1. WHY WOULDN"T THEY SHOW "LITTLE" effect...THEY HAD VERY LOW SI SCORES!!! IN FACT, All these "Substances" COMBINED did not match BRILACIDIN'S SI SCORE *426*. TO COMPARE THESE SUBSTANCES TO OR ANY SUBSTANCE in competition with BRILACIDIN...the substance being compared (which there are NONE) would be "SI" Score of 426...THERE ARE NO OTHERS! So, the comparative statement is comparing rotten apples to juicy oranges.
2. AGAIN...BRILACIN's SI's 426 SCORE is greater than ALL THOSE SUBSTANCES SI SCORE COMBINED and they showed "Little effect", therefore it is reasonable to expect Brilacidin, with 10X SI score of substances cited,...to show SIGNIFICANTLY MORE EFFECT on Covid viral suppression.
3. SAE COMPARISON? as is noted in quote...those OTHER SUBSTANCES "...led to SAE (severe adverse events and side effects) in human patients."...OK...but BRILACIDIN throughout PHASE II Clinical Trials for 5 Different Indications...BRILACIDIN has NEVER CAUSED a single SAE.
So what these "other" substances do it totally irrelevant to Brilacidin.
Quote:
"...several substances like Remdesivir, Lopinavir and Chloroquine were reported to repress viral replication in vitro. However, these compounds showed little effect on virus replication or led to severe adverse side effects in human patients." Bottom line: is that the
in vitro assays in cells did not predict clinical behavior.
Conclusion:
SUBSTANCES WITH Small SI SCORES showed small SUPRESSION of VIRAL SUPPRESSION in Clincial Trials...therefore Substances (Brilacidin) with EXTREMELY HIGH (HIGHEST) SI SCORE OF POTENTIAL THERAPEUTICS ... will likely demonstate in Clinical Trials EXTREMELY HIGH VIRAL SUPPRESSION in current clinicatl trials...compared to the substances sited.
Thank you for providing a post to further demonstrate the GREAT POTENTIAL of BRILACIDIN vs. Covid-19 IMO soon to be demonstrated in the current Clinical Trials!
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