That is why they do trials, to see if and how much a drug will do in a diverse population. We also have to remember, the severe and critical patients are suffering badly due to covid and typically other conditions in there overall health. These patients are very close to deaths door and no matter how well leronlimab works, it might be too late. Many of these patients are in bad shape even without covid. I think it was foolish to look at the mortality and guess which arm the deaths added up to, few here realized the patient population was very diverse with a wide range of conditions.