Hello all, First time posting, but I’ve been
Post# of 155038
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Posted On: 03/06/2021 6:48:17 PM
Hello all,
First time posting, but I’ve been following this board for some time. Thank you all for your insight and invaluable knowledge and opinions.
I didn’t expect my first post to quite go like this but without further ado, I need some insight on the below post I copied from the CYDY Reddit board about our recent results. Seems reasonable to me but I’m not sure if I’m missing anything.
Posted by
u/Large-Waltz796
5 hours ago
I did the calculation with spreadsheet for all possibilities on critical patients.
The results are: the placebo has 19 patients, 2 survived with discharge alive but all others 17 dead at day 28, the death rate is 89.47%. The Leronlimab has 43 patients, 12 discharge alive at day 28, 26 dead, 5 still in hospital, the death rate is 60.47%. The death reduction is 23.53% by (17x2-26)/(17x2). If the 5 patients in hospital survived later, the death reduction is 89.47%-60.47%=29.01%.
This calculation meets total critical patients 62, 28% discharge alive in Leronlimab, 11% discharge alive in placebo, the death reduction of 24% at day 28.
The p value for critical patients is 0.0021 with a small sample size (62).
This result is not a full approval due to small sample size which will be fixed by OLE, but it is DEFINITELY an EUA at current point.
Update: Even all 5 patients in hospital at day 28 dead, the p value is 0.0451 still less than 0.05
First time posting, but I’ve been following this board for some time. Thank you all for your insight and invaluable knowledge and opinions.
I didn’t expect my first post to quite go like this but without further ado, I need some insight on the below post I copied from the CYDY Reddit board about our recent results. Seems reasonable to me but I’m not sure if I’m missing anything.
Posted by
u/Large-Waltz796
5 hours ago
I did the calculation with spreadsheet for all possibilities on critical patients.
The results are: the placebo has 19 patients, 2 survived with discharge alive but all others 17 dead at day 28, the death rate is 89.47%. The Leronlimab has 43 patients, 12 discharge alive at day 28, 26 dead, 5 still in hospital, the death rate is 60.47%. The death reduction is 23.53% by (17x2-26)/(17x2). If the 5 patients in hospital survived later, the death reduction is 89.47%-60.47%=29.01%.
This calculation meets total critical patients 62, 28% discharge alive in Leronlimab, 11% discharge alive in placebo, the death reduction of 24% at day 28.
The p value for critical patients is 0.0021 with a small sample size (62).
This result is not a full approval due to small sample size which will be fixed by OLE, but it is DEFINITELY an EUA at current point.
Update: Even all 5 patients in hospital at day 28 dead, the p value is 0.0451 still less than 0.05
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