CERC-002 actually targets a different TNF unit TNF
Post# of 148169
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Posted On: 03/02/2021 10:54:00 PM
Re: Riztheinvestor #80510
CERC-002 actually targets a different TNF unit TNFSF14. TNFSF14 seems to have a lesser modulatory effect on inflammation then TNF-a which is what leronlimab downregulates.
It did get me wondering if CCR5 has an effect on TNFSF14. TNFSF14 production is induced through IL-2 and we know CCR5 blockade downregulates IL-2 through intracellular calcium downregulation and lowering of NFAT so CCR5 blockade would downregulate TNFSF14 along with TNF-a.
It did get me wondering if CCR5 has an effect on TNFSF14. TNFSF14 production is induced through IL-2 and we know CCR5 blockade downregulates IL-2 through intracellular calcium downregulation and lowering of NFAT so CCR5 blockade would downregulate TNFSF14 along with TNF-a.
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