First of all, remember the FDA provides guidance a
Post# of 36537
Use Google and look up transgenic mouse studies.
We are waiting to see if we make igG antibodies in the mice with the DR4 1 human allele. We really already know from the previous studies about the cd4, cd8 and giving long term immunity to a degree.
https://www.nature.com/articles/srep28093
https://academic.oup.com/rheumatology/article...97/2898681
https://pubmed.ncbi.nlm.nih.gov/27622300/