Techguru, The inhibition of CCL3 and CCL4 open
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Posted On: 01/24/2021 10:40:18 AM
Techguru,
The inhibition of CCL3 and CCL4 open other clinical applications as well, as Jlang noted a few days back:
CCL3's role in Hippocampal synaptic transmission, plasticity, and memory... CCR5 antagonism resolving CCL3's negative effects:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625372/
https://investorshangout.com/post/view?id=6022067
Multiple sclerosis (inhibition beyond RANTES):
https://pubmed.ncbi.nlm.nih.gov/31268406/
Elevated CSF concentration of CCL3 and CCL4 in relapsing remitting multiple sclerosis patients
Ohm20 has previously documented the impact of CCL5 inhibition in these conditions, but blocking CCL3 and CCL4 will likely increase clinical benefit.
Very cool and extremely exciting.
The inhibition of CCL3 and CCL4 open other clinical applications as well, as Jlang noted a few days back:
CCL3's role in Hippocampal synaptic transmission, plasticity, and memory... CCR5 antagonism resolving CCL3's negative effects:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625372/
https://investorshangout.com/post/view?id=6022067
Multiple sclerosis (inhibition beyond RANTES):
https://pubmed.ncbi.nlm.nih.gov/31268406/
Elevated CSF concentration of CCL3 and CCL4 in relapsing remitting multiple sclerosis patients
Ohm20 has previously documented the impact of CCL5 inhibition in these conditions, but blocking CCL3 and CCL4 will likely increase clinical benefit.
Very cool and extremely exciting.
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