or yesterday I saw someone with melanoma mets to t

or yesterday I saw someone with melanoma mets to the brain and wondered ...

https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14065

Quote:

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In this letter, we build up the rationale to utilize CCR5 as a therapeutic target for metastatic melanoma.

...

Taken together, the attenuation of signalling through CCR5
seems to help in modulating the deleterious effects of inflammation
while virtually causing no pathology with this attenuation.

...

In melanoma, the relevance of CCR5 is emphasized by the
finding that its ligand, CCL5, is highly expressed in advanced
melanomas while it is lowly expressed in low-stage disease.[33]
Decreased expression of both CCR5 and CCR3 associated with
positive therapy response to interleukin-2 and adoptive cell ther-
apy in melanoma.[34] This suggests that CCR5 acts as modulator of
the immune response allowing an enhanced immune response via
interleukin-2 signalling while also containing the activity of other
immune effectors.

In mice, the CCR5/CCL5 pathway enables neutrophilic infiltra-
tion in the tumor.[33,35] Immune cell infiltration is for the most part
looked for to mount an adequate immune response; however, sus-
tained neutrophil infiltration in the tumor can drive chronic inflam-
mation, which causes tumor progression.[36] Perhaps, CCR5 is in the
crossroads of an efficient anti-tumor immune response and an un-
controlled harmful inflammatory response.

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https://pubmed.ncbi.nlm.nih.gov/30474221/

Quote:

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Collectively, our results establish a critical role of CCR5 expressed by melanoma cells in cancer progression and reveal the novel mechanisms controlling this process, which suggests the prognostic value of CCR5 in melanoma patients and provides novel insights into CCR5-targeted strategies for melanoma treatment.

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I invested in CYDY for cancer, knowing HIV was a lock with good P3 data and big market. Covid is the icing on the cake that hopefully will get us to other indications much faster. If Covid P3 fails, then CYDY is still cheap for the HIV and cancer indications.