Is 100% receptor occupancy equivalent to CCR5delta32 homozygosity?
One answer is No, because homoCCR5d32 has no functional CCR5 available ALL the time, while 100% RO a few days after treatment with LL may come too late in the Covid / hyperinflammatory timeline.
If there was a correlation of RO and outcomes, one would think it would have been picked up in the Patterson work. The only correlation they showed (Int J Inf Dis? paper) was between CD8 levels and plasma viral load.
I think that LL doesn't help some patients, but almost all patients on LL will have close to 100% RO, so my hunch is that one shouldn't t expect a correlation.
The genetic population data is very interesting though.
One other genetics of Covid paper from a few weeks ago did find in a GWAS study there was a locus (3p21.31) that may have been related to CCR5, but they didn't explore or comment any further.