More evidence for dysregulated inflammatory respon
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Posted On: 12/30/2020 5:50:53 PM
More evidence for dysregulated inflammatory response in severe Covid.
https://www.nejm.org/doi/full/10.1056/NEJMc20...tured_home
Microvascular Injury in the Brains of Patients with Covid-19
Acute vascular injury, not just thrombotic events.
“ Punctate hypointensities on imaging in 10 patients corresponded to congested blood vessels (Figure 1C) with surrounding areas of fibrinogen leakage (Figure 1D and Fig. S1) and relatively intact vasculature (Figure 1E). Areas of linear hypointensities were interpreted as microhemorrhages (Figure 1F and Fig. S2). There was minimal perivascular inflammation in the specimens examined, but there was no vascular occlusion, as previously described in the Journal.1 Perivascular-activated microglia, macrophage infiltrates, and hypertrophic astrocytes were seen in 13 patients (Figure 1G and 1H, Fig. S3, and Table S4).2 There were CD3+ and CD8+ T cells in the perivascular spaces and in lumens adjacent to endothelial cells in 8 patients, which may have contributed to vascular injury (Figure 1I and 1J), as suggested in a previous report”
https://www.nejm.org/doi/full/10.1056/NEJMc20...tured_home
Microvascular Injury in the Brains of Patients with Covid-19
Acute vascular injury, not just thrombotic events.
“ Punctate hypointensities on imaging in 10 patients corresponded to congested blood vessels (Figure 1C) with surrounding areas of fibrinogen leakage (Figure 1D and Fig. S1) and relatively intact vasculature (Figure 1E). Areas of linear hypointensities were interpreted as microhemorrhages (Figure 1F and Fig. S2). There was minimal perivascular inflammation in the specimens examined, but there was no vascular occlusion, as previously described in the Journal.1 Perivascular-activated microglia, macrophage infiltrates, and hypertrophic astrocytes were seen in 13 patients (Figure 1G and 1H, Fig. S3, and Table S4).2 There were CD3+ and CD8+ T cells in the perivascular spaces and in lumens adjacent to endothelial cells in 8 patients, which may have contributed to vascular injury (Figure 1I and 1J), as suggested in a previous report”
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