JLang, Grow, Agreed, thanks for the information
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Posted On: 12/21/2020 12:46:24 PM
JLang, Grow,
Agreed, thanks for the information. imo there is cause for concern for two reasons:
1) The virus is mutating very rapidly. Mutations are normally selective in that virus "test" strains with more survivability outcomes.
2) The moa of vaccines (mostly mRNA) hinder in the stability of the protein spike. Viruses are very good at mutating to avoid immune targeting (antigenic drift). If one of these mutations "hits" the protein code we will be in trouble as far as vaccine efficacies previously reported. If one discovers the Achilles heel of something and then Achilles changes its heel one is in trouble
:
From the link that you posted (emphasis is mine):
As time goes by this is more likely to happen. Let's hope this is not the case but some degree of caution would indicated that therapeutics testing and development need to continue full blast.
Agreed, thanks for the information. imo there is cause for concern for two reasons:
1) The virus is mutating very rapidly. Mutations are normally selective in that virus "test" strains with more survivability outcomes.
2) The moa of vaccines (mostly mRNA) hinder in the stability of the protein spike. Viruses are very good at mutating to avoid immune targeting (antigenic drift). If one of these mutations "hits" the protein code we will be in trouble as far as vaccine efficacies previously reported. If one discovers the Achilles heel of something and then Achilles changes its heel one is in trouble
: From the link that you posted (emphasis is mine):
Quote:
One reason to be concerned, Rambaut says, is that among the 17 mutations are eight in the gene that encodes the spike protein on the viral surface, two of which are particularly worrisome. One, called N501Y, has previously been shown to increase how tightly the protein binds to the angiotensin-converting enzyme 2 receptor, its entry point into human cells. The other, named 69-70del, leads to the loss of two amino acids in the spike protein and has been found in viruses that eluded the immune response in some immunocompromised patients.
As time goes by this is more likely to happen. Let's hope this is not the case but some degree of caution would indicated that therapeutics testing and development need to continue full blast.
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