I spent a good chunk of time as an options/ futures trader. As much as there is money to be made, you and anyone else does not know the future. With options you can define risk and with discipline you can stick to a set of rules that keep you on track. With a small biotech that has no options and the potential to burst to the upside any time, there is no defined risk and no discipline that can get you out. I don’t care how responsible you are, an overnight gap, even a modest gap, will kill your portfolio. My opinion is that it is beyond stupid to short at any size a company like cytodyn. The only thing that I could fathom is shorting short term while holding an equal or greater long stock position. However, why risk missing out on the home run because you are trying to make $100?