"If you get the vaccine shot, and it works and you get antibodies which prevent the virus spreading in your blood stream, can you still get your nose and throat infected again and be infectious to others?"
I did not go to med school but the linings of your throat, nose and lungs are made up of living tissues. These tissues are made up of living cells. These cells are provided with oxygen, nutrients and building blocks by your blood stream to keep them healthy and allow them to reproduce.
The corona virus is inhaled and the virus attaches itself to the cells that make up the lining of your respiratory tract.
Once the virus is attached to a cell, the virus infects the cell by inserting its viral RNA into the cell. The RNA includes "instructions" which "turns on" your cell and each infected cell starts making copies of the virus in large quantities.
These new virus copies are released from your cells onto the linings of your airways, where they can infect other cells, which can make even more copies. The buildup of the released viruses in the fluids in your airways is what makes you infectious to others when these fluid droplets are expelled from your lungs.
When you are infected or vaccinated, your body produces antibodies to fight the virus and stop them from reproducing in your airway lining cells. The antibodies are delivered by your blood stream to the lining cells. The antibodies enter the cells and prevent the virus from multiplying within the cells. I don't think the virus is entering your blood stream.
If you are uninfected, have antibodies, and you inhale a quantity of virus from a contagious person, then your virus loading is going to be pretty low initially and you will be unlikely to infect others. With existing antibodies preventing the virus from multiplying within your cells, your viral loading remains low and the virus within you dies off. So you have broken the transmission train.
I suppose you could expel all or part of that virus that you initially inhaled before it dies off and "infect" someone else, but is that any worse than the third person getting it directly from the original source.
https://www.nytimes.com/interactive/2020/03/1...cells.html
I did not go to med school but the linings of your throat, nose and lungs are made up of living tissues. These tissues are made up of living cells. These cells are provided with oxygen, nutrients and building blocks by your blood stream to keep them healthy and allow them to reproduce.
The corona virus is inhaled and the virus attaches itself to the cells that make up the lining of your respiratory tract.
Once the virus is attached to a cell, the virus infects the cell by inserting its viral RNA into the cell. The RNA includes "instructions" which "turns on" your cell and each infected cell starts making copies of the virus in large quantities.
These new virus copies are released from your cells onto the linings of your airways, where they can infect other cells, which can make even more copies. The buildup of the released viruses in the fluids in your airways is what makes you infectious to others when these fluid droplets are expelled from your lungs.
When you are infected or vaccinated, your body produces antibodies to fight the virus and stop them from reproducing in your airway lining cells. The antibodies are delivered by your blood stream to the lining cells. The antibodies enter the cells and prevent the virus from multiplying within the cells. I don't think the virus is entering your blood stream.
If you are uninfected, have antibodies, and you inhale a quantity of virus from a contagious person, then your virus loading is going to be pretty low initially and you will be unlikely to infect others. With existing antibodies preventing the virus from multiplying within your cells, your viral loading remains low and the virus within you dies off. So you have broken the transmission train.
I suppose you could expel all or part of that virus that you initially inhaled before it dies off and "infect" someone else, but is that any worse than the third person getting it directly from the original source.
https://www.nytimes.com/interactive/2020/03/1...cells.html
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