There are two arguments against no increase in CD8
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Posted On: 12/04/2020 9:21:12 PM
There are two arguments against no increase in CD8+ T-cells by using leronlimab. Chronic or high level inflammation causes a drop in CD8+ T-cells due to exhaustion and lowering the inflammation significantly causes a rebound. Blocking CCR5 with leronlimab and therefore RANTES (CCL5) would reduce the TGF-B killing of CD8+ T-cells by TREGS.
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