“That is precisely why the fact that the are tak
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Posted On: 11/06/2020 4:03:05 PM
“That is precisely why the fact that the are taking a new look at 75% can be construed as positive: the statistician thinks that we can achieve both, a low p-value and high-enough power at this time.”
What’s your thoughts on the DSMC asking to review mortality data at 42 days? Is that an indication that the DSMC believes the 42 day mortality rate will be better than the 28 day rate they saw at 28 days? The DSMC didn’t recommend an adjustment to the protocol, which is good, but I’m still trying to figure out why they asked to look at 42 day mortality if 28 day mortality is assumably good/great.
What’s your thoughts on the DSMC asking to review mortality data at 42 days? Is that an indication that the DSMC believes the 42 day mortality rate will be better than the 28 day rate they saw at 28 days? The DSMC didn’t recommend an adjustment to the protocol, which is good, but I’m still trying to figure out why they asked to look at 42 day mortality if 28 day mortality is assumably good/great.
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