Reading the preprint here's another highlight from

Reading the preprint here's another highlight from page 7:

"To independently assess the impact of brilacidin on the virion and thus add support to the role of brilacidin as an inhibitor of viral entry, a direct virus inhibition assay was conducted akin to virus neutralization observed in the presence of antibodies. To that end, SARS-CoV-2 inoculum was incubated with brilacidin at 10µM concentration for 1 hour after which the treated inoculum
was used to infect Vero cells. In this experiment, the cells were not pre-treated with the inhibitor (brilacidin) prior to the infection. After 1 hour of infection, the inoculum was removed and replaced with fresh media without any inhibitor and the cells were maintained in inhibitor-free media for 24 hours. The infectious virus titer in the supernatant was quantified by plaque assay, which revealed a dramatic 90% reduction of virus titer (Figure 2E, indicated as [entry]). This
inhibition was approximately 25% higher than that observed when the cells were pre- and posttreated with brilacidin concomitantly (Figure 2E) supporting the concept that brilacidin has a direct inhibitory effect on the virus in a manner similar to the neutralization of antibodies, potentially by disrupting viral integrity and thus impairing the virion’s ability to complete the viral entry process"