The Remdesivir approval speaks volumes of our institutions.
I am not going to go to another tirade with the FDA, NIH, etc. You please take your own conclusions.
Please find below some of the results of the WHO study "WHO SOLIDARITY":
Now, if this drug (Remdesivir) works. Can somebody explain to me what happened with the WHO trial ???. Did the 30 countries got it all wrong (not some, ALL because if some had got is " right " the numbers would be better) ??? Are the deaths fake ???. Maybe they do not know how to count deaths ???, or maybe they were giving water to the patients instead of Remdesivir by mistake ??? (the p-value was 0.5 , that is exactly that can be expected when one gives water to the patients; I am dead serious here).
Maybe there was a confabulation with the 2750 patients and their families across the world to have them "exhibit" the same deaths as the placebo and recovery times as the rest of the patients for ... for .... (mmmm, for what ???)
Can somebody PLEASE help me to understand because there is only one way I can understand these results AND those carried out in china as well (some halted) in the context of approval in USA of the same drug.
But I promised I was not going to talk about the FDA of a country that has the worst death rate due to COVID in the world (unfortunately USA, my country).
I am not going to go to another tirade with the FDA, NIH, etc. You please take your own conclusions.
Please find below some of the results of the WHO study "WHO SOLIDARITY":
Quote:RESULTS
In 405 hospitals in 30 countries 11,266 adults were randomized, with 2750 allocated Remdesivir , 954 Hydroxychloroquine, 1411 Lopinavir, 651 Interferon plus Lopinavir, 1412 only Interferon, and 4088 no study drug. Compliance was 94-96% midway through treatment, with 2-6% crossover. 1253 deaths were reported (at median day 8, IQR 4-14). Kaplan-Meier 28-day mortality was 12% (39% if already ventilated at randomization, 10% otherwise).
Death rate ratios (with 95% CIs and numbers dead/randomized, each drug vs its control) were: Remdesivir RR=0.95 (0.81-1.11, p=0.50; 301/2743 active vs 303/2708 control), Hydroxychloroquine RR=1.19 (0.89-1.59, p=0.23; 104/947 vs 84/906), Lopinavir RR=1.00 (0.79-1.25, p=0.97; 148/1399 vs 146/1372) and Interferon RR=1.16 (0.96-1.39, p=0.11; 243/2050 vs 216/2050). No study drug definitely reduced mortality (in unventilated patients or any other subgroup of entry characteristics), initiation of ventilation or hospitalisation duration.
Quote:CONCLUSIONS These Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay. The mortality findings contain most of the randomized evidence on Remdesivir and Interferon, and are consistent with meta-analyses of mortality in all major trials.
Now, if this drug (Remdesivir) works. Can somebody explain to me what happened with the WHO trial ???. Did the 30 countries got it all wrong (not some, ALL because if some had got is " right " the numbers would be better) ??? Are the deaths fake ???. Maybe they do not know how to count deaths ???, or maybe they were giving water to the patients instead of Remdesivir by mistake ??? (the p-value was 0.5 , that is exactly that can be expected when one gives water to the patients; I am dead serious here).
Maybe there was a confabulation with the 2750 patients and their families across the world to have them "exhibit" the same deaths as the placebo and recovery times as the rest of the patients for ... for .... (mmmm, for what ???)
Can somebody PLEASE help me to understand because there is only one way I can understand these results AND those carried out in china as well (some halted) in the context of approval in USA of the same drug.
But I promised I was not going to talk about the FDA of a country that has the worst death rate due to COVID in the world (unfortunately USA, my country).
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