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Dvb, In cases where there are two groups each w

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Post# of 155133
(Total Views: 693)
Posted On: 10/06/2020 6:11:28 PM
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Posted By: TechGuru
Re: Dvb #60011
Dvb,

In cases where there are two groups each with a yes or not outcome (as in success or failure, or live and death) it is commonly to use the binomial distribution as opposed to a continuous distribution.

The good news is that, if we use this test between two binomials (one for LL and the other for placebo), the p-values are significantly lower than the T-Test with unequal variance .

Without starting a rabbit-hole discussion on mathematics and statistical methods, suffice to say that the p-value for 22-23 deaths LL/Placebo is very good for trial stoppage (I get 0.00482 for a 2-tailed test).

So we are all good with 22/23 Please note that this is a very high bar (16.9% deaths in LL and 35.4% deaths in SOC).

Sleeping uneasy nowadays and checking my telephone every 5 minutes from 5:30 A.M. waiting for the 6:00 A.M PR announcing significant data results obtained

Severe case of COD and a little of greed, I must admit.




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