The results you suggest are significant at p
Post# of 148282
(Total Views: 642)
Posted On: 09/29/2020 6:14:19 PM
The results you suggest are significant at p<.01, but I'm not sure that's the exact question to ask.
The suggested .045 is not the required result at interim analysis.
As I understand the penalty, is relates to the required significance at 390 enrollees, assuming it is not ended early. It translates to 1 to 2 fewer deaths in the 260 person leronlimab arm.
My view: dissemination of very good results, even if they don't cause a halt for efficacy, will accelerate remaining enrollment.
The suggested .045 is not the required result at interim analysis.
As I understand the penalty, is relates to the required significance at 390 enrollees, assuming it is not ended early. It translates to 1 to 2 fewer deaths in the 260 person leronlimab arm.
My view: dissemination of very good results, even if they don't cause a halt for efficacy, will accelerate remaining enrollment.
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