Journal article supporting chemotaxis in severe Covid 19.
MAIT cell activation and dynamics associated with COVID-19 disease severity
https://immunology.sciencemag.org/content/5/51/eabe1670
Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.”
CCR5 receptors highly expressed in peripheral MAITs, so diminution, if not blockade, of MAIT trafficking achievable with leronlimab.
“ The interpretation of preferential recruitment of MAIT cells to the inflamed airways gains further support from the distinct tissue homing profile of MAIT cells with expression of several relevant chemokine receptors, such as CCR6, CXCR6, CCR5 and CXCR3 (35). This notion has further support in the literature, as activation and homing to sites of inflammation is consistent with observations in obesity and diabetes (41), multiple sclerosis (42), and in inflammatory bowel disease (43)”
My expectations for CD12 are undiminished.
MAIT cell activation and dynamics associated with COVID-19 disease severity
https://immunology.sciencemag.org/content/5/51/eabe1670
Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.”
CCR5 receptors highly expressed in peripheral MAITs, so diminution, if not blockade, of MAIT trafficking achievable with leronlimab.
“ The interpretation of preferential recruitment of MAIT cells to the inflamed airways gains further support from the distinct tissue homing profile of MAIT cells with expression of several relevant chemokine receptors, such as CCR6, CXCR6, CCR5 and CXCR3 (35). This notion has further support in the literature, as activation and homing to sites of inflammation is consistent with observations in obesity and diabetes (41), multiple sclerosis (42), and in inflammatory bowel disease (43)”
My expectations for CD12 are undiminished.
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