While I'm loathe to post on another drug's success
Post# of 145808
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First, I'll mention that, looking at its MOA, Ohm noted that if this drug works, leronlimab should work in even better.
Basically their Phase III trial is using the same 7-category scale we have as a secondary endpoint. To be admitted, you have to be a 3 or 4 on that scale - getting oxygen but not intubated. "Clinical recovery" is defined as moving to a "2" score (hospitalized, no oxygen), progression was moving to a "5" (requiring intubation).
They claimed 60% increase in patients hitting clinical recovery (significant at p=.005) and a 50% reduction in patients progressing (not claimed as significant). So,
(1) Based on NEWS2 and SAEs, it sounds like our Phase 2 would have done similarly or better on comparable patient pop,
(2) on Phase 3, we can recreate exactly their results for our data for an apple-to-apples comparison,
(3) this interim was specified not by the number of patients, but by the number of recoveries, nice,
(4) we now know what results can cause a stopped trial,
(5) this drug is competition, but not for the trial of the sickest,
(6) OncoImmune also wrote a lousy press release IMO - my headline should have been: "OncoImmune in COVID 19 - Phase 3 trial halted for efficacy: Stat significant 60% increase in patients improving, 50% reduction in progressions,"
(7) Biospace noted the press release but has not otherwise commented in its news stream.
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