Start with clickbait title: COVID-19 Storms:
Post# of 145746
Quote:
COVID-19 Storms: Bradykinin In, Cytokine Out?
— Papers poke holes in cytokine storm as gene expression study offers a new theory
Except, they don't. These are computer simulations. If you think in vitro was nonrepresentative, that would go several times more for in digito. According to the Peanut Gallery:
Quote:
That's consistent with a growing sense of doubt cast upon the "unproven dogma" of the cytokine storm, as Italian anesthesiologist Maurizio Cecconi, MD, called it on Twitter
If you're looking at & for the wrong cytokines, perhaps. Maurizio would rather his "unproven dogma" be something that can't be accurately measured, currently.
Quote:
Measuring bradykinin itself is challenging because it is formed and degraded during the process of drawing blood,
How droll. At best:
Quote:
However, it's also possible, or even likely, that both types of responses are occurring simultaneously in COVID-19 infection, commented Allen Kaplan, MD, of the Medical University of South Carolina.
Speaks for itself really. Now this:
Quote:
Still, the findings are "really intriguing," and could also explain some aspects of the abnormal coagulation associated with COVID-19 patients, Brown said. In animal studies, bradykinin has been shown to boost levels of tissue plasminogen activator (tPA), a protein involved in the breakdown of blood clots, she explained.
Sound pretty incongruous with the coagulopathies associated with some CV19 cases.
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