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Start with clickbait title: COVID-19 Storms:

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Post# of 154851
(Total Views: 501)
Posted On: 09/13/2020 4:03:25 PM
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Posted By: JLang
Re: dfwl28 #55605
Start with clickbait title:
Quote:


COVID-19 Storms: Bradykinin In, Cytokine Out?
— Papers poke holes in cytokine storm as gene expression study offers a new theory



Except, they don't. These are computer simulations. If you think in vitro was nonrepresentative, that would go several times more for in digito. According to the Peanut Gallery:

Quote:
That's consistent with a growing sense of doubt cast upon the "unproven dogma" of the cytokine storm, as Italian anesthesiologist Maurizio Cecconi, MD, called it on Twitter



If you're looking at & for the wrong cytokines, perhaps. Maurizio would rather his "unproven dogma" be something that can't be accurately measured, currently.

Quote:
Measuring bradykinin itself is challenging because it is formed and degraded during the process of drawing blood,



How droll. At best:

Quote:
However, it's also possible, or even likely, that both types of responses are occurring simultaneously in COVID-19 infection, commented Allen Kaplan, MD, of the Medical University of South Carolina.



Speaks for itself really. Now this:

Quote:

Still, the findings are "really intriguing," and could also explain some aspects of the abnormal coagulation associated with COVID-19 patients, Brown said. In animal studies, bradykinin has been shown to boost levels of tissue plasminogen activator (tPA), a protein involved in the breakdown of blood clots, she explained.



Sound pretty incongruous with the coagulopathies associated with some CV19 cases.



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