What is known about multiple sclerosis and CCR5 sh
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Posted On: 09/12/2020 5:59:58 PM
What is known about multiple sclerosis and CCR5 shows that the disease is CCR5 driven and CCR5 blockade has an extremely high likelihood of reversing it.
Multiple sclerosis is caused by destruction of the myelin sheath and degradation of neurons. The destruction of myelin is due to inflammation but first CCR5 bearing macrophages have to be able to cross over into the central nervous system. The macrophages use matrix metalloproteinase to do this. CCR5 blockade downregulates matrix metalloproteinase lowering that invasion.
Guidance of macrophages by CCL5 to the myelin sheath in response to autoimmunity to myelin basic protein and proteolipid protein would be shut down by leronlimab.
Multiple sclerosis symptoms and lesions are correlated with increases in IL-6 and interferon-gamma, leronlimab downregulates both. As you noted leronlimab also lowers inflammatory macrophages through macrophage differentiation.
Multiple sclerosis is caused by destruction of the myelin sheath and degradation of neurons. The destruction of myelin is due to inflammation but first CCR5 bearing macrophages have to be able to cross over into the central nervous system. The macrophages use matrix metalloproteinase to do this. CCR5 blockade downregulates matrix metalloproteinase lowering that invasion.
Guidance of macrophages by CCL5 to the myelin sheath in response to autoimmunity to myelin basic protein and proteolipid protein would be shut down by leronlimab.
Multiple sclerosis symptoms and lesions are correlated with increases in IL-6 and interferon-gamma, leronlimab downregulates both. As you noted leronlimab also lowers inflammatory macrophages through macrophage differentiation.
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