My post may have been abstruse. First long hauler
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Posted On: 09/09/2020 11:07:40 AM
My post may have been abstruse. First long haulers have negligible viral titres, and we do not see the flip in CD4/CD8 ratios thereby at least in that population, quite a few investigators do not believe this is a rantes driven condition. Also I am not suggesting this will be the treatment, just an intriguing hypothesis that may promote clinical studies. Again we have seen outstanding results with steroids in clinical practice for different diseases.
I am trying to share the data that is the results of basic science. Also most of the side effects of steroids are dose related. Hydroxy may also play a role. I wanted to share an example:
AITL, a form of lymphoma. Most oncologist use B cell chemoprotocols, for treatment, very toxic. An AITL study group composed of thought leaders in oncology was formed about 5 years ago their work created an unusual protocol: pulse dose gram dosing of steroids. I saw a patient with baseball size nodes disappear in several days. In pulmonary fibrosis and ITP (which changed surgical splenectomy as the primary treatment) again with impressive results. Oh, I should give the full name angio immunoblastic T cell lymphoma, steroids have been used with success in the treatment Sezary disease (cutaneous lymphoma).
Gram dosing is used for a very short course, maintenance therapy is usually less than 5 mg of predisone, referred to, as physiological dosing.
Those nasty side effects are seen in much higher doses. I have noticed many posters have an impressive curiosity in this disease, so I wanted to share a recent paper that may offer a plausible explanation for the "pediatric paradox": children have a much lower expression of ACE-2 receptors, the viral entry point. Further studies in receptor expression may also address the asymptomatic positive antibody patients.
Finally dr580 my post was a response to your response to reallypeople, although he did not offer scientific proof of his speculation, on going research MAY offer proof of his statements.
My post was not intended to "trash" leronilmab, just to communicate some new scientific hypotheses.
Sorry for the long response.
I am trying to share the data that is the results of basic science. Also most of the side effects of steroids are dose related. Hydroxy may also play a role. I wanted to share an example:
AITL, a form of lymphoma. Most oncologist use B cell chemoprotocols, for treatment, very toxic. An AITL study group composed of thought leaders in oncology was formed about 5 years ago their work created an unusual protocol: pulse dose gram dosing of steroids. I saw a patient with baseball size nodes disappear in several days. In pulmonary fibrosis and ITP (which changed surgical splenectomy as the primary treatment) again with impressive results. Oh, I should give the full name angio immunoblastic T cell lymphoma, steroids have been used with success in the treatment Sezary disease (cutaneous lymphoma).
Gram dosing is used for a very short course, maintenance therapy is usually less than 5 mg of predisone, referred to, as physiological dosing.
Those nasty side effects are seen in much higher doses. I have noticed many posters have an impressive curiosity in this disease, so I wanted to share a recent paper that may offer a plausible explanation for the "pediatric paradox": children have a much lower expression of ACE-2 receptors, the viral entry point. Further studies in receptor expression may also address the asymptomatic positive antibody patients.
Finally dr580 my post was a response to your response to reallypeople, although he did not offer scientific proof of his speculation, on going research MAY offer proof of his statements.
My post was not intended to "trash" leronilmab, just to communicate some new scientific hypotheses.
Sorry for the long response.
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