Blafarm,
Excellent interview and information. Dr. J. Lalezari has lots of experience and has his heart in the right place. He chocked when asked why minorities are taking the brunt of the COVID-19 pandemic and could not go anymore for a while !!!
My favorite part:
Question: So Russia’s president Vladimir Putin has registered the first COVID-19 vaccine without going through phase three trials. What do you think about this and why are these three phases of a vaccine trial important:
Answer:
Great stuff ...
Excellent interview and information. Dr. J. Lalezari has lots of experience and has his heart in the right place. He chocked when asked why minorities are taking the brunt of the COVID-19 pandemic and could not go anymore for a while !!!
My favorite part:
Question: So Russia’s president Vladimir Putin has registered the first COVID-19 vaccine without going through phase three trials. What do you think about this and why are these three phases of a vaccine trial important:
Answer:
Quote:Yeah, I think the authoritarian regimes, you know, in Brazil, Russia and the United States have had a very hard time managing the pandemic because management of this, a problem of this magnitude, requires good governance, and smart governance, and these folks, you know, in these authoritarian regimes, are not there because they are good governors, they are there because their strong man and able to suppress dissent ,control the vote, manipulate media, but has nothing to do with being competent in governance ah, and so, you know, Putin can claim to have a vaccine but it is not tested it is meaningless claim and I would say that there are real concerns whether we we're ever gonna have a vaccine, ah, that is being a bummer part of the talk …
If I’m excited that Leronlimab is going to be the first drug that actually works to treat COVID 19, I have to also report that I am somewhat leery and skeptical of whether a vaccine is possible, Russian or otherwise; and the reason for that is that, you know, first of all, there are other coronavirus infections and what we know is that their floor so that commonly occur and recur every year and just because you had previous infection doesn’t protect you from getting re-infected. So that’s the biology of coronaviruses that it comes around every year and there’s no doubt that in my mind that some of the determinants of who goes on to have a bad disease and who doesn’t must reflect in part who’s already been exposed and has partial immune responses, specifically T-cell responses, so that the two arms of the immune system antibodies and T-cells they mean system anybody else and re measure antibodies because is a lot easier lot easier but probably is the T-cells that are more important particularly for intracellular pathogens like viruses, but we, you know, the experiment that nature has done is that you you guys get when you're when you get a cold in the winter like 1 out of 4 of them is a coronavirus and then you get over it and then you get it again the next year, so your prior exposure while it might mediate the severity of the next illness, it doesn't, it's not protective, and if you look at the antibody responses in patients who had COVID-19, in folks that had mild infection some of them aren't even developing an antibody and folks with more severe infection, they are developing an antibody but it’s attenuating very quickly over period of months.
And so those immune responses that are being developed in response to the infection do not appear to be particularly long lived or long lived and I are in constant now, that said, we're measuring antibodies, then again the T-cell responses are far more determinative and important, but if you talking about a vaccine then you’re talking about developing something that is gonna improve upon what Mother Nature herself is able to do and we’ve never really done that for there’s a reason we don’t have an aids vaccine.
Great stuff ...
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