Ritz, Leronlimab may absolutely help even in ad
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Leronlimab may absolutely help even in advanced TNBC. Remember that blocking CCR5 not only reduces metastasis but reduces the ability of tumor cells to maintain the micro-environment that enables them to avoid other chemotherapies and the body's immune system.
Here is a recent article (Oct 2019):
Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology/
https://cancerres.aacrjournals.org/content/79...1-tag-here
It is quite dense, but the important section of the abstract states:
"The misexpression of CCR5 in epithelial cells, induced upon oncogenic transformation, hijacks this migratory phenotype [Regulatory T-Cells]. CCR5 reexpression augments resistance to DNA-damaging agents and is sufficient to induce cancer metastasis.
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