CT Another really great article: And it all sound
Post# of 153778
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Posted On: 09/04/2020 7:11:53 AM
CT Another really great article: And it all sounds so very familiar to the CYDY community. Thanks
Excerpt: "Our receptor of interest, the chemokine receptor, is involved in substantial inflammatory diseases of the central nervous system (CNS) and functions in the recruitment and immigration of immune cells. These receptors are mainly distributed in microglia and recruited peripheral blood monocytes in the CNS (El, 2010), while they are rarely expressed on neuronal cell membranes under normal physiological conditions (Huerta et al., 2004). Increased expression of CCR5 in the CNS is an inflammatory response to many neuropathological diseases, e.g., stroke (Joy et al., 2019), Parkinson’s disease (Huerta et al., 2004), multiple sclerosis (SRensen et al., 1999; Trebst et al., 2001), and Rasmussen encephalitis (Bien Christian et al., 2013; Varadkar et al., 2014). At the beginning of this year, an article published in Cell (Joy et al., 2019) further attracted everyone’s attention to the association between CCR5 and neuronal plasticity that is potentially relevant to neuroinflammation and AD. In this review, we will elucidate the intricate association between AD, inflammation, and CCR5.
Excerpt: "Our receptor of interest, the chemokine receptor, is involved in substantial inflammatory diseases of the central nervous system (CNS) and functions in the recruitment and immigration of immune cells. These receptors are mainly distributed in microglia and recruited peripheral blood monocytes in the CNS (El, 2010), while they are rarely expressed on neuronal cell membranes under normal physiological conditions (Huerta et al., 2004). Increased expression of CCR5 in the CNS is an inflammatory response to many neuropathological diseases, e.g., stroke (Joy et al., 2019), Parkinson’s disease (Huerta et al., 2004), multiple sclerosis (SRensen et al., 1999; Trebst et al., 2001), and Rasmussen encephalitis (Bien Christian et al., 2013; Varadkar et al., 2014). At the beginning of this year, an article published in Cell (Joy et al., 2019) further attracted everyone’s attention to the association between CCR5 and neuronal plasticity that is potentially relevant to neuroinflammation and AD. In this review, we will elucidate the intricate association between AD, inflammation, and CCR5.
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