Pete: Not sure about what would be a high range
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Posted On: 08/07/2020 1:00:04 PM
Pete:
Not sure about what would be a high range, but this is what I found.
Calculating the Average Selectivity Index (SI) for Each Compound
The selectivity index (SI) is a ratio that measures the window between cytotoxicity and antiviral activity by dividing the given AVA value into the TOX value (AVA/TOX). The higher the SI ratio, the theoretically more effective and safe a drug would be during in vivo treatment for a given viral infection. The ideal drug would be cytotoxic only at very high concentrations and have antiviral activity at very low concentrations, thus yielding a high SI value (high AVA/low TOX) and thereby able to eliminate the target virus at concentrations well below its cytotoxic concentration. The selectivity index of a compound is a widely accepted parameter used to express a compound’s in vitro efficacy in the inhibition of virus replication.
Not sure about what would be a high range, but this is what I found.
Calculating the Average Selectivity Index (SI) for Each Compound
The selectivity index (SI) is a ratio that measures the window between cytotoxicity and antiviral activity by dividing the given AVA value into the TOX value (AVA/TOX). The higher the SI ratio, the theoretically more effective and safe a drug would be during in vivo treatment for a given viral infection. The ideal drug would be cytotoxic only at very high concentrations and have antiviral activity at very low concentrations, thus yielding a high SI value (high AVA/low TOX) and thereby able to eliminate the target virus at concentrations well below its cytotoxic concentration. The selectivity index of a compound is a widely accepted parameter used to express a compound’s in vitro efficacy in the inhibition of virus replication.
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