Playing devil’s advocate here, what if secondary
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Playing devil’s advocate here, what if secondary are met and primary at 14 is just so so because we met it so early and placebo caught up by day 14? Approved?
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I think there is a chance, that is what occured due to a flawed Primary endpoint. They should have made the primary day 0, 3, 7, 14 so we could show the progression.
But again, in a phase 2 trial, the primary and secondary endpoints are essentially interchangeable. Its this way on purpose, as you want to identify the best endpoint to use in a phase 3 trial if required.